pI: 6.8796 |
Length (AA): 1730 |
MW (Da): 189119 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 175 | 4tth (B) | 15 | 163 | 33.00 | 0.44 | 0.44 | 0.170851 | 0.76 |
27 | 222 | 2h34 (A) | 16 | 224 | 13.00 | 0.055 | 0.06 | -0.0349052 | 0.72 |
29 | 831 | 5dfz (B) | 29 | 716 | 29.00 | 0 | 0.99 | 0.228262 | 1.77 |
717 | 843 | 4ffb (C) | 28 | 169 | 9.00 | 0 | 0.32 | 0.10531 | -0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129368)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G29380 | phosphoinositide-3-kinase, regulatory subunit 4, p150 |
Brugia malayi | Bm1_22785 | Protein kinase domain containing protein |
Candida albicans | CaO19.7773 | similar to S. cerevisiae VPS15 (YBR097W) |
Candida albicans | CaO19.7776 | similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting |
Candida albicans | CaO19.7775 | similar to S. cerevisiae VPS15 (YBR097W) |
Candida albicans | CaO19.130 | similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting |
Candida albicans | CaO19.129 | similar to S. cerevisiae VPS15 (YBR097W) |
Caenorhabditis elegans | CELE_ZK930.1 | Protein ZK930.1, isoform B |
Dictyostelium discoideum | DDB_G0282627 | VPS15 family protein kinase |
Drosophila melanogaster | Dmel_CG9746 | immune response deficient 1 |
Echinococcus granulosus | EgrG_000725500 | phosphoinositide 3 kinase regulatory subunit 4 |
Entamoeba histolytica | EHI_044190 | protein kinase with WD repeats |
Echinococcus multilocularis | EmuJ_000725500 | phosphoinositide 3 kinase regulatory subunit 4 |
Homo sapiens | ENSG00000196455 | phosphoinositide-3-kinase, regulatory subunit 4 |
Loa Loa (eye worm) | LOAG_03673 | VPS15 protein kinase |
Loa Loa (eye worm) | LOAG_11033 | hypothetical protein |
Mus musculus | ENSMUSG00000032571 | phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150 |
Oryza sativa | 4331010 | Os02g0796700 |
Saccharomyces cerevisiae | YBR097W | Vps15p |
Schistosoma japonicum | Sjp_0032570 | Phosphoinositide 3-kinase regulatory subunit 4, putative |
Schistosoma japonicum | Sjp_0032530 | ko:K08333 phosphoinositide-3-kinase, regulatory subunit 4, p150, putative |
Schistosoma mansoni | Smp_123610 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.001936.06 | |
Schmidtea mediterranea | mk4.001936.03 | Phosphoinositide 3-kinase regulatory subunit 4 |
Schmidtea mediterranea | mk4.001936.02 | Serine/threonine kinase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | phosphoinositide-3-kinase, regulatory subunit 4 | Compounds | References |